I have only two strong opinions on tabs-vs-spaces: 1) I should not have to care or even think about it - it's 2014, for goodness sake, why is this still a thing?? - and 2) mixing indentation styles should be a hard error in Python.
It's great that Pythonista enables me to tap out a quick test on my iPhone with minimal tedium, but I do most of my hacking on my iPad with a Bluetooth keyboard.
Because of that, I've switched to tabs for indentation; with tabs to I can get to the "logical" beginning of a line with cmd-left + right a few times (say, 2-4 on average), but with 4-space soft tabs that was 8-16 - or more - right arrows. Tedium. I started having to care.
(Also, "Convert Indentation" cleans up trailing whitespace? Woo Hoo! I'm gonna run that baby all the time!)