Put the following code to your sites packages
folder and create a shortcut under the wrench tool.
#Comment/Uncomment selected lines
import editor
text = editor.get_text()
selection = editor.get_line_selection()
selected_text = text[selection[0]:selection[1]]
is_comment = selected_text.strip().startswith('#')
replacement = ''
for line in selected_text.splitlines():
if is_comment:
if line.strip().startswith('#'):
replacement += line[line.find('#') + 1:] + '\n'
else:
replacement += line + '\n'
else:
replacement += '#' + line + '\n'
editor.replace_text(selection[0], selection[1], replacement)
editor.set_selection(selection[0], selection[0] + len(replacement) - 1)