I've only had two issues with Pythonista and they've both been caused by iOS 13. One was it not being able to access it's cloud folder. That was fixed in the latest iOS 4 public beta. The other issue is not being able to open and pin folders. This is because Apple depreciated the ability to open folders from the dialog used in Pythonista and they'll have to implement a different dialog for folder opening.
Both issues are a pain, to be sure, but that's what happens when you use beta software.